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6-[2-(1H-indol-6-yl)ethyl]pyridin-2-amine
- Development stage
- Preclinical
- Lead developer
- Janssen Pharmaceutica
- Modality
- Small Molecules
01
Overview
6-[2-(1H-indol-6-yl)ethyl]pyridin-2‑amine is a synthetic small molecule featuring a pyridine ring and an indole moiety connected via an ethyl chain[1][3][9]. It is classified as a pyridin‑2‑amine derivative. The compound has attracted interest in medicinal chemistry and pharmacology due to its potential biological activities, particularly as an enzyme inhibitor[1][8]. Computational studies suggest it may act as a potent inhibitor of beta-secretase 1 (BACE1), with nanomolar affinity, indicating possible utility in neurodegenerative disease research such as Alzheimer's disease[8]. However, there are no approved indications or clinical trials reported for this compound to date[2].
- Other names
- 6-(2-(1H-indol-6-yl)ethyl)pyridin-2-amine2-pyridinamine, 6-(2-(1H-indol-6-yl)ethyl)-
02
Targets
BACE1 (Beta-site APP-cleaving enzyme 1)
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